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Over the years, he began to liken these two types of children to two very different flowers: dandelions and orchids.\u003c/p>\n\u003cp>Broadly speaking, says \u003ca href=\"https://profiles.ucsf.edu/tom.boyce\" target=\"_blank\" rel=\"noopener\">Boyce\u003c/a> — who also has spent nearly 40 years studying the human stress response, especially in children — most kids tend to be like dandelions, fairly resilient and able to cope with stress and adversity in their lives. But a minority of kids, those he calls “orchid children,” are more sensitive and biologically reactive to their circumstances, which makes it harder for them to deal with stressful situations.[contextly_sidebar id=”IvCr36i4S1EYhLjR3xMTzjOHrdmBka5u”]\u003c/p>\n\u003cp>Like the flower, Boyce says, “the orchid child is the child who shows great sensitivity and susceptibility to both bad and good environments in which he or she finds herself or himself.”\u003c/p>\n\u003cp>Given supportive, nurturing conditions, orchid children can thrive — especially, Boyce says, if they have the comfort of a regular routine.\u003c/p>\n\u003cp>“Orchid children seem to thrive on having things like dinner every night in the same place at the same time with the same people, having certain kinds of rituals that the family goes through week to week, month to month,” he says. “This kind of routine and sameness of life from day to day, week to week, seems to be something that is helpful to kids with these great susceptibilities.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Boyce’s new book is \u003cem>The Orchid and the Dandelion: Why Some Children Struggle and How All Can Thri\u003c/em>ve\u003cem>. \u003c/em>He appeared this week on \u003ca href=\"https://www.npr.org/programs/fresh-air/2019/03/04/699939149\" target=\"_blank\" rel=\"noopener\">Fresh Air\u003c/a> with host Dave Davies to discuss it.\u003cem>\u003cbr>\n\u003c/em>\u003c/p>\n\u003chr>\n\u003cp>\u003cstrong>Interview highlights:\u003c/strong>\u003c/p>\n\u003cp>\u003cstrong>On the lab test he did to determine if a child is an orchid or a dandelion\u003c/strong>\u003c/p>\n\u003cp>We made an effort to try to understand these individual differences between children in how they respond biologically to mild, common kinds of challenges and stressors, and the way we did that was we brought them into a laboratory setting. We sat them down in front of an examiner — a research assistant that they had not previously met — and we asked them to go through a series of mildly challenging tasks. These were things like recounting a series of digits that the examiner asked them to say and increasing that from first three to four to five digits; having them just engage in a conversation with this examiner, who might ask them about their birthday or presents or something about their family. That, in itself, is a challenge for a young child. Putting a drop of lemon juice on the tongue was another kind of challenge that was evocative of these changes in biological response. …\u003c/p>\n\u003cp>We measured their stress response using the two primary stress response systems in the human brain. [One was] the \u003ca href=\"http://www.yourhormones.info/hormones/cortisol/\" target=\"_blank\" rel=\"noopener\">cortisol system\u003c/a>, which is centered in the hypothalamus of the brain. This is the system that releases the stress hormone cortisol, which has profound effects on both immune function and cardiovascular functioning.\u003c/p>\n\u003cp>And then the second stress response system is the \u003ca href=\"https://faculty.washington.edu/chudler/auto.html\" target=\"_blank\" rel=\"noopener\">autonomic nervous system\u003c/a>, or the “fight-or-flight” system. This is the one that is responsible for the sweaty palms and a little bit of tremulousness, the dilation of the pupils, all of these things that we associate with the fight-or-flight response. So we were monitoring responsivity and both of those systems as the children went through these mildly challenging tasks. …\u003c/p>\n\u003cp>We found that there were huge differences [among] children. There were some children at the high end of the spectrum, who had dramatic reactivity in both the cortisol system and the fight-or-flight system, and there were other children who had almost no biological response to the challenges that we presented to them.\u003c/p>\n\u003cp>\u003cstrong>On how a child’s responsivity to stressors can be connected to physical and emotional behavioral outcomes\u003c/strong>\u003c/p>\n\u003cp>We find in our research that the same kinds of patterns of response are found for both physical illnesses, like severe respiratory disease, pneumonia, asthma and so on, as well as or more [in] emotional behavioral outcomes, like anxiety and depression and externalizing kinds of symptoms. So we believe that the same patterns of susceptibility that we find in the orchid child versus the dandelion child work themselves out not only for physical ailments but also for psychosocial and emotional problems. And we believe that the same kinds of underlying biological processes work for both. …\u003c/p>\n\u003cp>We do know, for example, that these two stress response systems … the cortisol system and the fight-or-flight system, the autonomic nervous system, both of those have powerful effects on the immune system, so they can alter the child’s ability to build an immune defense against viruses and bacteria that he or she may be exposed to. And they have also powerful effects on the cardiovascular system, so [they] could eventually, in adult life, predispose to developing hypertension, high blood pressure or other kinds of cardiovascular risk.\u003c/p>\n\u003cp>\u003cstrong>On how children’s experiences can vary, even within the same family\u003c/strong>\u003c/p>\n\u003cp>The experience of children within a given family, the siblings within a family — although they are being reared with the same parents in the same house in the same neighborhood — they actually have quite different kinds of experiences that depend upon the birth order of the child, the gender of the child, to some extent differences in genetic sequence. It is a way of talking about these dramatic differences that kids from different birth orders and different genders have within a given family.\u003c/p>\n\u003cp>\u003cstrong>On pushing orchid kids to stretch to do new or difficult things\u003c/strong>\u003c/p>\n\u003cp>I think that this is probably the most difficult parenting task in raising an orchid child. The parent of an orchid child needs to walk this very fine line between, on the one hand, not pushing them into circumstances that are really going to overwhelm them and make them greatly fearful, but, on the other hand, not protecting them so much that they don’t have experiences of mastery of these kinds of fearful situations.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cem>Sam Briger and Seth Kelley produced and edited the \u003ca href=\"https://www.npr.org/sections/health-shots/2019/03/04/699979387/is-your-child-an-orchid-or-a-dandelion-unlocking-the-science-of-sensitive-kids\" target=\"_blank\" rel=\"noopener\">audio version\u003c/a> of this interview, which aired on Fresh Air. Bridget Bentz and Molly Seavy-Nesper adapted it for the Web.\u003c/em>\u003c/p>\n\u003cdiv class=\"fullattribution\">\u003cem>Copyright 2019 \u003ca href=\"https://www.npr.org/programs/fresh-air/\" target=\"_blank\" rel=\"noopener\">Fresh Air\u003c/a>.\u003c/em>\u003c/div>\n\n","blocks":[],"excerpt":"Some kids seem resilient from the start — readily able to cope with stress and adversity. But pediatrician Thomas Boyce says biologically reactive kids need more support to thrive.","status":"publish","parent":0,"modified":1704848815,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":22,"wordCount":1090},"headData":{"title":"Some Kids Are Just More Sensitive, and Here's the Science to Show It | KQED","description":"Some kids seem resilient from the start — readily able to cope with stress and adversity. But pediatrician Thomas Boyce says biologically reactive kids need more support to thrive.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"source":"NPR","sticky":false,"nprImageCredit":"Michael H","nprByline":"Dave Davies\u003c/br>NPR","nprImageAgency":"Getty Images","nprStoryId":"699979387","nprApiLink":"http://api.npr.org/query?id=699979387&apiKey=MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004","nprHtmlLink":"https://www.npr.org/sections/health-shots/2019/03/04/699979387/is-your-child-an-orchid-or-a-dandelion-unlocking-the-science-of-sensitive-kids?ft=nprml&f=699979387","nprRetrievedStory":"1","nprPubDate":"Wed, 06 Mar 2019 11:23:00 -0500","nprStoryDate":"Mon, 04 Mar 2019 15:38:00 -0500","nprLastModifiedDate":"Mon, 04 Mar 2019 19:34:15 -0500","nprAudio":"https://ondemand.npr.org/anon.npr-mp3/npr/fa/2019/03/20190304_fa_01.mp3?orgId=427869011&topicId=1030&d=2191&p=13&story=699979387&ft=nprml&f=699979387","nprAudioM3u":"http://api.npr.org/m3u/1700126425-86883c.m3u?orgId=427869011&topicId=1030&d=2191&p=13&story=699979387&ft=nprml&f=699979387","audioTrackLength":2192,"path":"/science/1938819/some-kids-are-just-more-sensitive-and-heres-the-science-to-show-it","audioUrl":"https://ondemand.npr.org/anon.npr-mp3/npr/fa/2019/03/20190304_fa_01.mp3?orgId=427869011&topicId=1030&d=2191&p=13&story=699979387&ft=nprml&f=699979387","parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Dr. Thomas Boyce, an emeritus professor of pediatrics and psychiatry at the University of California, San Francisco, has treated children who seem to be completely unflappable and unfazed by their surroundings — as well as those who are extremely sensitive to their environments. Over the years, he began to liken these two types of children to two very different flowers: dandelions and orchids.\u003c/p>\n\u003cp>Broadly speaking, says \u003ca href=\"https://profiles.ucsf.edu/tom.boyce\" target=\"_blank\" rel=\"noopener\">Boyce\u003c/a> — who also has spent nearly 40 years studying the human stress response, especially in children — most kids tend to be like dandelions, fairly resilient and able to cope with stress and adversity in their lives. But a minority of kids, those he calls “orchid children,” are more sensitive and biologically reactive to their circumstances, which makes it harder for them to deal with stressful situations.\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>Like the flower, Boyce says, “the orchid child is the child who shows great sensitivity and susceptibility to both bad and good environments in which he or she finds herself or himself.”\u003c/p>\n\u003cp>Given supportive, nurturing conditions, orchid children can thrive — especially, Boyce says, if they have the comfort of a regular routine.\u003c/p>\n\u003cp>“Orchid children seem to thrive on having things like dinner every night in the same place at the same time with the same people, having certain kinds of rituals that the family goes through week to week, month to month,” he says. “This kind of routine and sameness of life from day to day, week to week, seems to be something that is helpful to kids with these great susceptibilities.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Boyce’s new book is \u003cem>The Orchid and the Dandelion: Why Some Children Struggle and How All Can Thri\u003c/em>ve\u003cem>. \u003c/em>He appeared this week on \u003ca href=\"https://www.npr.org/programs/fresh-air/2019/03/04/699939149\" target=\"_blank\" rel=\"noopener\">Fresh Air\u003c/a> with host Dave Davies to discuss it.\u003cem>\u003cbr>\n\u003c/em>\u003c/p>\n\u003chr>\n\u003cp>\u003cstrong>Interview highlights:\u003c/strong>\u003c/p>\n\u003cp>\u003cstrong>On the lab test he did to determine if a child is an orchid or a dandelion\u003c/strong>\u003c/p>\n\u003cp>We made an effort to try to understand these individual differences between children in how they respond biologically to mild, common kinds of challenges and stressors, and the way we did that was we brought them into a laboratory setting. We sat them down in front of an examiner — a research assistant that they had not previously met — and we asked them to go through a series of mildly challenging tasks. These were things like recounting a series of digits that the examiner asked them to say and increasing that from first three to four to five digits; having them just engage in a conversation with this examiner, who might ask them about their birthday or presents or something about their family. That, in itself, is a challenge for a young child. Putting a drop of lemon juice on the tongue was another kind of challenge that was evocative of these changes in biological response. …\u003c/p>\n\u003cp>We measured their stress response using the two primary stress response systems in the human brain. [One was] the \u003ca href=\"http://www.yourhormones.info/hormones/cortisol/\" target=\"_blank\" rel=\"noopener\">cortisol system\u003c/a>, which is centered in the hypothalamus of the brain. This is the system that releases the stress hormone cortisol, which has profound effects on both immune function and cardiovascular functioning.\u003c/p>\n\u003cp>And then the second stress response system is the \u003ca href=\"https://faculty.washington.edu/chudler/auto.html\" target=\"_blank\" rel=\"noopener\">autonomic nervous system\u003c/a>, or the “fight-or-flight” system. This is the one that is responsible for the sweaty palms and a little bit of tremulousness, the dilation of the pupils, all of these things that we associate with the fight-or-flight response. So we were monitoring responsivity and both of those systems as the children went through these mildly challenging tasks. …\u003c/p>\n\u003cp>We found that there were huge differences [among] children. There were some children at the high end of the spectrum, who had dramatic reactivity in both the cortisol system and the fight-or-flight system, and there were other children who had almost no biological response to the challenges that we presented to them.\u003c/p>\n\u003cp>\u003cstrong>On how a child’s responsivity to stressors can be connected to physical and emotional behavioral outcomes\u003c/strong>\u003c/p>\n\u003cp>We find in our research that the same kinds of patterns of response are found for both physical illnesses, like severe respiratory disease, pneumonia, asthma and so on, as well as or more [in] emotional behavioral outcomes, like anxiety and depression and externalizing kinds of symptoms. So we believe that the same patterns of susceptibility that we find in the orchid child versus the dandelion child work themselves out not only for physical ailments but also for psychosocial and emotional problems. And we believe that the same kinds of underlying biological processes work for both. …\u003c/p>\n\u003cp>We do know, for example, that these two stress response systems … the cortisol system and the fight-or-flight system, the autonomic nervous system, both of those have powerful effects on the immune system, so they can alter the child’s ability to build an immune defense against viruses and bacteria that he or she may be exposed to. And they have also powerful effects on the cardiovascular system, so [they] could eventually, in adult life, predispose to developing hypertension, high blood pressure or other kinds of cardiovascular risk.\u003c/p>\n\u003cp>\u003cstrong>On how children’s experiences can vary, even within the same family\u003c/strong>\u003c/p>\n\u003cp>The experience of children within a given family, the siblings within a family — although they are being reared with the same parents in the same house in the same neighborhood — they actually have quite different kinds of experiences that depend upon the birth order of the child, the gender of the child, to some extent differences in genetic sequence. It is a way of talking about these dramatic differences that kids from different birth orders and different genders have within a given family.\u003c/p>\n\u003cp>\u003cstrong>On pushing orchid kids to stretch to do new or difficult things\u003c/strong>\u003c/p>\n\u003cp>I think that this is probably the most difficult parenting task in raising an orchid child. The parent of an orchid child needs to walk this very fine line between, on the one hand, not pushing them into circumstances that are really going to overwhelm them and make them greatly fearful, but, on the other hand, not protecting them so much that they don’t have experiences of mastery of these kinds of fearful situations.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cem>Sam Briger and Seth Kelley produced and edited the \u003ca href=\"https://www.npr.org/sections/health-shots/2019/03/04/699979387/is-your-child-an-orchid-or-a-dandelion-unlocking-the-science-of-sensitive-kids\" target=\"_blank\" rel=\"noopener\">audio version\u003c/a> of this interview, which aired on Fresh Air. Bridget Bentz and Molly Seavy-Nesper adapted it for the Web.\u003c/em>\u003c/p>\n\u003cdiv class=\"fullattribution\">\u003cem>Copyright 2019 \u003ca href=\"https://www.npr.org/programs/fresh-air/\" target=\"_blank\" rel=\"noopener\">Fresh Air\u003c/a>.\u003c/em>\u003c/div>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/science/1938819/some-kids-are-just-more-sensitive-and-heres-the-science-to-show-it","authors":["byline_science_1938819"],"categories":["science_32","science_3151","science_39","science_16","science_3890","science_40"],"tags":["science_5181","science_3838","science_807","science_1342","science_5155"],"featImg":"science_1938820","label":"source_science_1938819"},"science_182996":{"type":"posts","id":"science_182996","meta":{"index":"posts_1591205157","site":"science","id":"182996","score":null,"sort":[1439398163000]},"guestAuthors":[],"slug":"how-the-songbird-learns-to-sing","title":"How the Songbird Learns to Sing","publishDate":1439398163,"format":"standard","headTitle":"How the Songbird Learns to Sing | KQED","labelTerm":{"site":"science"},"content":"\u003cp>Like the best opera divas, songbirds must train their voices from an early age. But instead of studying for years at a conservatory, the birds’ brains are hardwired to experiment with complicated musical passages.\u003c/p>\n\u003cp>Now, scientists from UCSF have honed in on the precise brain pathways that songbirds use to learn and tune their highly specialized vocalizations. Their \u003ca href=\"http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4078.html\">results\u003c/a>, published recently in the journal \u003ca href=\"http://www.nature.com/neuro/index.html\">Nature Neuroscience\u003c/a>, may have implications for understanding how our own brains learn new vocal tricks.\u003c/p>\n\u003cp>Baby zebra finches don’t make a peep for their first 30 days. Instead, they listen to adults around them and develop a mental model of what a song should sound like.\u003c/p>\n\u003cp>“That template tells them what they’re practicing to get to,” says Hamish Mehaffey, a postdoctoral researcher at UCSF and lead author of the study. “It’s like how the syllables we’re exposed to when we’re young shape our ability to learn new languages later.”\u003c/p>\n\u003cp>The young finches then spend the next few months experimenting with trial-and-error to perfect their own songs.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003cstrong>Listen to a finch song:\u003c/strong>\u003cbr>\n[audio mp3=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2015/08/Song.mp3\"][/audio]\u003c/p>\n\u003cp>“If a new song is better [than the previous song], then they keep whatever neural activity they used to make that song,” explains Mehaffey.\u003c/p>\n\u003cp>Scientists already knew that certain parts of the brain were involved in learning new songs, but until now, nobody knew exactly how these pathways were wired in the brain or how the new, experimental songs were generated.\u003c/p>\n\u003cp>\u003cstrong>The Musical Brain\u003c/strong>\u003c/p>\n\u003cp>The researchers needed a way to measure activity of different brain structures and how these structures interact to produce song. So, they started with brain slices from zebra finches.\u003c/p>\n\u003cp>By isolating certain regions of the brain, they could stimulate the pathways involved in song production and then record the activity of cells that are involved in actually making the song.\u003c/p>\n\u003cp>The scientists could also identify the neurotransmitters and chemicals that activated or blocked each pathway.\u003c/p>\n\u003cp>In the slices, the researchers discovered that the birds’ creativity-generator involves a structure analogous to the human basal ganglia.\u003c/p>\n\u003cp>This dense cluster of cells at the base of the brain stem is basically the same in all kinds of vertebrate animals, from lampreys to humans. It’s involved in almost everything we do, from thoughts and emotions to motor activity.\u003c/p>\n\u003cp>“It’s difficult to study something like that because it could literally be involved in anything,” says Mehaffey. “But using finch song, we’ve been able to learn a lot about how the basal ganglia works normally and how it helps us learn new things.”\u003c/p>\n\u003cfigure id=\"attachment_182998\" class=\"wp-caption aligncenter\" style=\"max-width: 1685px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-182998\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o.jpg\" alt=\"Zebra Finches are native to Australia but have become excellent lab models for scientists to study the neuroscience of song learning.\" width=\"1685\" height=\"1266\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o.jpg 1685w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-400x301.jpg 400w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-800x601.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-1440x1082.jpg 1440w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-1180x887.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-960x721.jpg 960w\" sizes=\"(max-width: 1685px) 100vw, 1685px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Zebra Finches are native to Australia but have become excellent lab models for scientists to study the neuroscience of song learning. \u003ccite>(Phil McIver/flickr)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>From Bird Brain to Human Learning\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>The scientists were also able to show that the same chemicals that blocked the creativity generators in the brain slices also prevented live birds from modifying their songs as adults.\u003c/p>\n\u003cp>“That gives us confidence that what they found in the slice is actually what’s at work in the intact bird,” says Franz Goller, a biology professor at the University of Utah, who also studies the neurobiology of finch song.\u003c/p>\n\u003cp>Goller says that the brain pathways involved in finch learning are probably similar in other animals, so the findings might ultimately help us understand how we and other animals learn new vocal tricks.\u003c/p>\n\u003cp>“There’s quite a bit of evidence that, at least in terms of core circuitry, learned vocal behavior in humans also has these multi-path systems,” he says. \u003c/p>\n\u003cp>\u003c/p>\n\u003cp>“I could easily imagine that this is a highly dedicated pathway for vocal behavior, and it might be used in all kinds of motor skill learning.”\u003c/p>\n\n","blocks":[],"excerpt":"UCSF researchers have uncovered the brain pathways that songbirds use to learn and modify their songs","status":"publish","parent":0,"modified":1704931446,"stats":{"hasAudio":true,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":23,"wordCount":663},"headData":{"title":"How the Songbird Learns to Sing | KQED","description":"UCSF researchers have uncovered the brain pathways that songbirds use to learn and modify their songs","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"sticky":false,"path":"/science/182996/how-the-songbird-learns-to-sing","audioUrl":"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2015/08/Song.mp3","audioDuration":null,"audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Like the best opera divas, songbirds must train their voices from an early age. But instead of studying for years at a conservatory, the birds’ brains are hardwired to experiment with complicated musical passages.\u003c/p>\n\u003cp>Now, scientists from UCSF have honed in on the precise brain pathways that songbirds use to learn and tune their highly specialized vocalizations. Their \u003ca href=\"http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4078.html\">results\u003c/a>, published recently in the journal \u003ca href=\"http://www.nature.com/neuro/index.html\">Nature Neuroscience\u003c/a>, may have implications for understanding how our own brains learn new vocal tricks.\u003c/p>\n\u003cp>Baby zebra finches don’t make a peep for their first 30 days. Instead, they listen to adults around them and develop a mental model of what a song should sound like.\u003c/p>\n\u003cp>“That template tells them what they’re practicing to get to,” says Hamish Mehaffey, a postdoctoral researcher at UCSF and lead author of the study. “It’s like how the syllables we’re exposed to when we’re young shape our ability to learn new languages later.”\u003c/p>\n\u003cp>The young finches then spend the next few months experimenting with trial-and-error to perfect their own songs.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cstrong>Listen to a finch song:\u003c/strong>\u003cbr>\n\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"audio","attributes":{"named":{"mp3":"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2015/08/Song.mp3","label":""},"numeric":[]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>“If a new song is better [than the previous song], then they keep whatever neural activity they used to make that song,” explains Mehaffey.\u003c/p>\n\u003cp>Scientists already knew that certain parts of the brain were involved in learning new songs, but until now, nobody knew exactly how these pathways were wired in the brain or how the new, experimental songs were generated.\u003c/p>\n\u003cp>\u003cstrong>The Musical Brain\u003c/strong>\u003c/p>\n\u003cp>The researchers needed a way to measure activity of different brain structures and how these structures interact to produce song. So, they started with brain slices from zebra finches.\u003c/p>\n\u003cp>By isolating certain regions of the brain, they could stimulate the pathways involved in song production and then record the activity of cells that are involved in actually making the song.\u003c/p>\n\u003cp>The scientists could also identify the neurotransmitters and chemicals that activated or blocked each pathway.\u003c/p>\n\u003cp>In the slices, the researchers discovered that the birds’ creativity-generator involves a structure analogous to the human basal ganglia.\u003c/p>\n\u003cp>This dense cluster of cells at the base of the brain stem is basically the same in all kinds of vertebrate animals, from lampreys to humans. It’s involved in almost everything we do, from thoughts and emotions to motor activity.\u003c/p>\n\u003cp>“It’s difficult to study something like that because it could literally be involved in anything,” says Mehaffey. “But using finch song, we’ve been able to learn a lot about how the basal ganglia works normally and how it helps us learn new things.”\u003c/p>\n\u003cfigure id=\"attachment_182998\" class=\"wp-caption aligncenter\" style=\"max-width: 1685px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-182998\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o.jpg\" alt=\"Zebra Finches are native to Australia but have become excellent lab models for scientists to study the neuroscience of song learning.\" width=\"1685\" height=\"1266\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o.jpg 1685w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-400x301.jpg 400w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-800x601.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-1440x1082.jpg 1440w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-1180x887.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2015/08/19497700484_9e9e1c3e67_o-960x721.jpg 960w\" sizes=\"(max-width: 1685px) 100vw, 1685px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Zebra Finches are native to Australia but have become excellent lab models for scientists to study the neuroscience of song learning. \u003ccite>(Phil McIver/flickr)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>From Bird Brain to Human Learning\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>The scientists were also able to show that the same chemicals that blocked the creativity generators in the brain slices also prevented live birds from modifying their songs as adults.\u003c/p>\n\u003cp>“That gives us confidence that what they found in the slice is actually what’s at work in the intact bird,” says Franz Goller, a biology professor at the University of Utah, who also studies the neurobiology of finch song.\u003c/p>\n\u003cp>Goller says that the brain pathways involved in finch learning are probably similar in other animals, so the findings might ultimately help us understand how we and other animals learn new vocal tricks.\u003c/p>\n\u003cp>“There’s quite a bit of evidence that, at least in terms of core circuitry, learned vocal behavior in humans also has these multi-path systems,” he says. \u003c/p>\n\u003cp>\u003c/p>\n\u003cp>“I could easily imagine that this is a highly dedicated pathway for vocal behavior, and it might be used in all kinds of motor skill learning.”\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/science/182996/how-the-songbird-learns-to-sing","authors":["8639"],"categories":["science_30","science_35","science_40"],"tags":["science_163","science_807"],"featImg":"science_182999","label":"science"},"science_22736":{"type":"posts","id":"science_22736","meta":{"index":"posts_1591205157","site":"science","id":"22736","score":null,"sort":[1413816221000]},"guestAuthors":[],"slug":"bay-area-scientists-artfully-present-their-research-in-oakland-exhibit","title":"Bay Area Scientists Artfully Present Their Research in Oakland Exhibit","publishDate":1413816221,"format":"aside","headTitle":"Bay Area Scientists Artfully Present Their Research in Oakland Exhibit | KQED","labelTerm":{"site":"science"},"content":"\u003cfigure id=\"attachment_22737\" class=\"wp-caption alignnone\" style=\"max-width: 800px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/brains.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-22737\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/brains.jpg\" alt=\"Stained brain slices\" width=\"800\" height=\"450\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Stained primate brain slices, currently on display in the art show Experimental Space. (Sara M. Freeman)\u003c/figcaption>\u003c/figure>\n\u003cp>A few dozen large gray brains are printed on transparencies and arranged neatly on a light table. They’re the first images to show which parts of primate brains are receptive to the much-hyped “love hormone” oxytocin.\u003c/p>\n\u003cp>You’d never know that, though, from staring at the table of brains. It sits starkly in the middle of an art gallery, without so much as an informational plaque on the wall.\u003c/p>\n\u003cfigure id=\"attachment_22740\" class=\"wp-caption alignright\" style=\"max-width: 288px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/24_ExperimentalSpace-288x132.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-22740\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/24_ExperimentalSpace-288x132.jpg\" alt=\"MRI of fruit fly\" width=\"288\" height=\"132\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">MRI of fruit fly suspended in fluid, currently on display in Experimental Space. (\u003ca title=\"Brian Null - Stanford\" href=\"http://cmgm.stanford.edu/~bnull/\">Brian Null\u003c/a>)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cb>The aesthetics of scientific research\u003c/b>\u003c/p>\n\u003cp>“\u003ca title=\"Aggregate Space - Experimental Space\" href=\"http://www.aggregatespace.com/\">Experimental Space\u003c/a>” is the latest show at Oakland art gallery Aggregate Space, consisting of images and videos created by scientists in the course of their research. Gallery director Conrad M. Meyers II conceived the idea, and brought on Selene Foster and Christopher Reiger of the \u003ca title=\"BAASICS\" href=\"http://www.baasics.com/\">Bay Area Art and Science Interdisciplinary Collaborative Sessions\u003c/a> as enthusiastic co-hosts.\u003c/p>\n\u003cp>The trio sent out an open call for submissions, but found it challenging to fill the show. “We didn’t say no to much,” said Meyers. “We said no to actual artists.” Most scientists, whose idea of showing their work is a conference presentation or a journal publication, were hesitant about the idea. “This is taking away their ability to frame it,” said Reiger. “It’s risky. Or they just don’t get it.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Science is full of framing. Research papers are long and dull because they explain every methodological decision, label each figure ten different ways, run several independent statistical analyses, and finally list any future study that could disprove the results.\u003c/p>\n\u003cfigure id=\"attachment_22739\" class=\"wp-caption alignleft\" style=\"max-width: 288px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/arnaud_martin-288x162.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-22739\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/arnaud_martin-288x162.jpg\" alt=\"mutant shrimp\" width=\"288\" height=\"162\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Mutant shrimp, currently on display in Experimental Space, by \u003ca title=\"Arnaud Martin\" href=\"http://www.heliconius.org/author/arnaud-martin/\">Arnaud Martin\u003c/a>. (Aaron Rosenstreich)\u003c/figcaption>\u003c/figure>\n\u003cp>Take all that away, and you’re free to appreciate the pure aesthetics of a food web diagram or a mutant shrimp.\u003c/p>\n\u003cp>According to Meyers, the aim of Aggregate Space is to display art that gives, “The feeling that you’ll never in your life understand the whole story.” There could hardly be a more appropriate sentiment for an image snatched from the annals of research and plopped into an art gallery.\u003c/p>\n\u003cp>Do the displays in “Experimental Space” count as “art” even though they weren’t created with aesthetics in mind? Can they still be “science” once they’ve been deliberately divorced from their objective context?\u003c/p>\n\u003cp>\u003cb>A scientist who embraces subjectivity\u003c/b>\u003c/p>\n\u003cp>According to \u003ca title=\"Sara M. Freeman\" href=\"http://smfreeman.wordpress.com/\">Sara Freeman\u003c/a>, the UC Davis neuroscientist whose stained slices of brain tissue are on display, even the thoroughly-explained science in journals isn’t really all that objective.\u003c/p>\n\u003cp>We’re often taught, simplistically, that science is the objective process we use to uncover the fundamental truths of our world. But in graduate school, Freeman discovered that every scientist makes choice after subjective choice: which part of the brain to focus on, which statistics to use, which people to include in a control group.\u003c/p>\n\u003cp>“The more you think you know about the area you’re working in, the more you realize how much we really don’t understand, and how subjective a lot of that knowledge really is,” she said.\u003c/p>\n\u003cp>She eventually worked through her crisis of faith, and accepted that decisions must be made. In fact, she says that taking responsibility for them can be empowering. “It’s all subjective, but if you are aware of it, you can work to come up with something more objective.”\u003c/p>\n\u003cp>\u003cstrong>Solving the primate brain puzzle\u003c/strong>\u003c/p>\n\u003cp>Freeman’s field of research, the effects of oxytocin on social behavior, is full of \u003ca title=\"The Dark Side of Oxytocin - Ed Yong\" href=\"http://blogs.discovermagazine.com/notrocketscience/2010/11/29/the-dark-side-of-oxytocin-much-more-than-just-a-love-hormone/#.VER2L9Sx15R\">fascinating discoveries that can’t yet be fully explained\u003c/a>. In humans oxytocin has been associated with trust and empathy, maternal care and sexual relationships–but our understanding of how the brain receives oxytocin signals is based primarily on work in rodents. This is only so useful for understanding ourselves. Rodent social interactions are dominated by smells, unlike the visual and auditory social cues of most primates.\u003c/p>\n\u003cp>Unfortunately, the chemicals that scientists use to map oxytocin receptors in rodent brains don’t work as well in primates. Instead of binding exclusively to oxytocin receptors, the chemicals turn promiscuous, attaching themselves to receptors for both oxytocin and another hormone called vasopressin.\u003c/p>\n\u003cfigure id=\"attachment_22738\" class=\"wp-caption alignright\" style=\"max-width: 288px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/brain_slices-288x126.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-22738\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/brain_slices-288x126.jpg\" alt=\"brain slices\" width=\"288\" height=\"126\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Rhesus macaque brains by Sara M. Freeman, currently on display in Experimental Space. (Aaron Rosenstreich)\u003c/figcaption>\u003c/figure>\n\u003cp>Freeman has developed a new technique to tell which receptor is which. She uses a precise concentration of an entirely different molecule to tie up the vasopressin receptors, forcing the promiscuous binding chemicals into monogamy with oxytocin receptors.\u003c/p>\n\u003cp>This restricted binding revealed that the primate she was studying, the rhesus macaque, has oxytocin receptors in parts of its brain that deal with both vision and hearing. Freeman also found receptors in regions of higher-order processing, which suggests more nuanced behavioral effects than are seen in rodents. These brain maps will almost certainly help us understand the complexity of the oxytocin system, and refine the molecule’s use in medical treatment.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>To my mind, that usefulness adds significantly to their aesthetic appeal.\u003c/p>\n\n","blocks":[],"excerpt":"“\u003ca title=\"Aggregate Space - Experimental Space\" href=\"http://www.aggregatespace.com/\">Experimental Space\u003c/a>” is the latest show at Oakland art gallery Aggregate Space, consisting of images and videos created by scientists in the course of their research.","status":"publish","parent":0,"modified":1704932745,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":22,"wordCount":893},"headData":{"title":"Bay Area Scientists Artfully Present Their Research in Oakland Exhibit | KQED","description":"“Experimental Space” is the latest show at Oakland art gallery Aggregate Space, consisting of images and videos created by scientists in the course of their research.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"sticky":false,"path":"/science/22736/bay-area-scientists-artfully-present-their-research-in-oakland-exhibit","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_22737\" class=\"wp-caption alignnone\" style=\"max-width: 800px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/brains.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-22737\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/brains.jpg\" alt=\"Stained brain slices\" width=\"800\" height=\"450\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Stained primate brain slices, currently on display in the art show Experimental Space. (Sara M. Freeman)\u003c/figcaption>\u003c/figure>\n\u003cp>A few dozen large gray brains are printed on transparencies and arranged neatly on a light table. They’re the first images to show which parts of primate brains are receptive to the much-hyped “love hormone” oxytocin.\u003c/p>\n\u003cp>You’d never know that, though, from staring at the table of brains. It sits starkly in the middle of an art gallery, without so much as an informational plaque on the wall.\u003c/p>\n\u003cfigure id=\"attachment_22740\" class=\"wp-caption alignright\" style=\"max-width: 288px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/24_ExperimentalSpace-288x132.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-22740\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/24_ExperimentalSpace-288x132.jpg\" alt=\"MRI of fruit fly\" width=\"288\" height=\"132\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">MRI of fruit fly suspended in fluid, currently on display in Experimental Space. (\u003ca title=\"Brian Null - Stanford\" href=\"http://cmgm.stanford.edu/~bnull/\">Brian Null\u003c/a>)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cb>The aesthetics of scientific research\u003c/b>\u003c/p>\n\u003cp>“\u003ca title=\"Aggregate Space - Experimental Space\" href=\"http://www.aggregatespace.com/\">Experimental Space\u003c/a>” is the latest show at Oakland art gallery Aggregate Space, consisting of images and videos created by scientists in the course of their research. Gallery director Conrad M. Meyers II conceived the idea, and brought on Selene Foster and Christopher Reiger of the \u003ca title=\"BAASICS\" href=\"http://www.baasics.com/\">Bay Area Art and Science Interdisciplinary Collaborative Sessions\u003c/a> as enthusiastic co-hosts.\u003c/p>\n\u003cp>The trio sent out an open call for submissions, but found it challenging to fill the show. “We didn’t say no to much,” said Meyers. “We said no to actual artists.” Most scientists, whose idea of showing their work is a conference presentation or a journal publication, were hesitant about the idea. “This is taking away their ability to frame it,” said Reiger. “It’s risky. Or they just don’t get it.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Science is full of framing. Research papers are long and dull because they explain every methodological decision, label each figure ten different ways, run several independent statistical analyses, and finally list any future study that could disprove the results.\u003c/p>\n\u003cfigure id=\"attachment_22739\" class=\"wp-caption alignleft\" style=\"max-width: 288px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/arnaud_martin-288x162.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-22739\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/arnaud_martin-288x162.jpg\" alt=\"mutant shrimp\" width=\"288\" height=\"162\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Mutant shrimp, currently on display in Experimental Space, by \u003ca title=\"Arnaud Martin\" href=\"http://www.heliconius.org/author/arnaud-martin/\">Arnaud Martin\u003c/a>. (Aaron Rosenstreich)\u003c/figcaption>\u003c/figure>\n\u003cp>Take all that away, and you’re free to appreciate the pure aesthetics of a food web diagram or a mutant shrimp.\u003c/p>\n\u003cp>According to Meyers, the aim of Aggregate Space is to display art that gives, “The feeling that you’ll never in your life understand the whole story.” There could hardly be a more appropriate sentiment for an image snatched from the annals of research and plopped into an art gallery.\u003c/p>\n\u003cp>Do the displays in “Experimental Space” count as “art” even though they weren’t created with aesthetics in mind? Can they still be “science” once they’ve been deliberately divorced from their objective context?\u003c/p>\n\u003cp>\u003cb>A scientist who embraces subjectivity\u003c/b>\u003c/p>\n\u003cp>According to \u003ca title=\"Sara M. Freeman\" href=\"http://smfreeman.wordpress.com/\">Sara Freeman\u003c/a>, the UC Davis neuroscientist whose stained slices of brain tissue are on display, even the thoroughly-explained science in journals isn’t really all that objective.\u003c/p>\n\u003cp>We’re often taught, simplistically, that science is the objective process we use to uncover the fundamental truths of our world. But in graduate school, Freeman discovered that every scientist makes choice after subjective choice: which part of the brain to focus on, which statistics to use, which people to include in a control group.\u003c/p>\n\u003cp>“The more you think you know about the area you’re working in, the more you realize how much we really don’t understand, and how subjective a lot of that knowledge really is,” she said.\u003c/p>\n\u003cp>She eventually worked through her crisis of faith, and accepted that decisions must be made. In fact, she says that taking responsibility for them can be empowering. “It’s all subjective, but if you are aware of it, you can work to come up with something more objective.”\u003c/p>\n\u003cp>\u003cstrong>Solving the primate brain puzzle\u003c/strong>\u003c/p>\n\u003cp>Freeman’s field of research, the effects of oxytocin on social behavior, is full of \u003ca title=\"The Dark Side of Oxytocin - Ed Yong\" href=\"http://blogs.discovermagazine.com/notrocketscience/2010/11/29/the-dark-side-of-oxytocin-much-more-than-just-a-love-hormone/#.VER2L9Sx15R\">fascinating discoveries that can’t yet be fully explained\u003c/a>. In humans oxytocin has been associated with trust and empathy, maternal care and sexual relationships–but our understanding of how the brain receives oxytocin signals is based primarily on work in rodents. This is only so useful for understanding ourselves. Rodent social interactions are dominated by smells, unlike the visual and auditory social cues of most primates.\u003c/p>\n\u003cp>Unfortunately, the chemicals that scientists use to map oxytocin receptors in rodent brains don’t work as well in primates. Instead of binding exclusively to oxytocin receptors, the chemicals turn promiscuous, attaching themselves to receptors for both oxytocin and another hormone called vasopressin.\u003c/p>\n\u003cfigure id=\"attachment_22738\" class=\"wp-caption alignright\" style=\"max-width: 288px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/brain_slices-288x126.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-22738\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/10/brain_slices-288x126.jpg\" alt=\"brain slices\" width=\"288\" height=\"126\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Rhesus macaque brains by Sara M. Freeman, currently on display in Experimental Space. (Aaron Rosenstreich)\u003c/figcaption>\u003c/figure>\n\u003cp>Freeman has developed a new technique to tell which receptor is which. She uses a precise concentration of an entirely different molecule to tie up the vasopressin receptors, forcing the promiscuous binding chemicals into monogamy with oxytocin receptors.\u003c/p>\n\u003cp>This restricted binding revealed that the primate she was studying, the rhesus macaque, has oxytocin receptors in parts of its brain that deal with both vision and hearing. Freeman also found receptors in regions of higher-order processing, which suggests more nuanced behavioral effects than are seen in rodents. These brain maps will almost certainly help us understand the complexity of the oxytocin system, and refine the molecule’s use in medical treatment.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>To my mind, that usefulness adds significantly to their aesthetic appeal.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/science/22736/bay-area-scientists-artfully-present-their-research-in-oakland-exhibit","authors":["6324"],"categories":["science_30"],"tags":["science_635","science_807"],"featImg":"science_22737","label":"science"},"science_19200":{"type":"posts","id":"science_19200","meta":{"index":"posts_1591205157","site":"science","id":"19200","score":null,"sort":[1405000822000]},"guestAuthors":[],"slug":"communicating-science-through-an-artistic-lens-at-stanford","title":"Communicating Science Through an Artistic Lens at Stanford","publishDate":1405000822,"format":"aside","headTitle":"Communicating Science Through an Artistic Lens at Stanford | KQED","labelTerm":{"site":"science"},"content":"\u003cfigure id=\"attachment_19209\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/lioncubs.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-19209\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/lioncubs.jpg\" alt=\"behavior of lion cubs in the wild\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The behavior of lion cubs in the wild is far removed from the study of brain development in the lab. Sue McConnell pays careful attention to both, one as a photographer and the other as a scientist. (Susan McConnell)\u003c/figcaption>\u003c/figure>\n\u003cp>Stanford scientist Sue McConnell will be one of 15 U.S. professors to receive $1 million over the next five years from the \u003ca title=\"HHMI 2014 Professors\" href=\"http://www.hhmi.org/news/hhmi-puts-top-scientists-classroom\">Howard Hughes Medical Institute\u003c/a>. The grant supports creative approaches to science education; McConnell will use it to sustain a program that teaches biology seniors to communicate science to the public through art.\u003c/p>\n\u003cfigure id=\"attachment_19204\" class=\"wp-caption alignright\" style=\"max-width: 267px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/page4-1089-full.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"wp-image-19204 size-full\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/page4-1089-full.jpg\" alt=\"Alwali - The Protecting Friend\" width=\"267\" height=\"383\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">“Alwali – The Protecting Friend,” a graphic novel by Rosy Karna about the science and stigma of lymphatic filariasis. (Susan McConnell)\u003c/figcaption>\u003c/figure>\n\u003cp>As a \u003ca title=\"McConnell Lab\" href=\"http://stanford.edu/group/skmlab/index.html\">developmental neurobiologist\u003c/a>, McConnell studies how brain cells are created and wired together, but she gets out of the lab in a dramatic way as a \u003ca title=\"McConnell Photography\" href=\"http://www.susankmcconnell.com/7-2/\">conservation photographer\u003c/a>. Her images of Namibian elephants have been on the cover of \u003ci>Smithsonian\u003c/i> magazine. “I understand how potent the arts can be in communicating science,” she says—a potency she sees as necessary for policy change. “It’s pretty clear that information isn’t having the impact on public decisions that we’d hoped.”\u003c/p>\n\u003cp>This view motivated McConnell to create “\u003ca title=\"The Senior Reflection\" href=\"http://web.stanford.edu/~suemcc/TSR/index.html\">The Senior Reflection\u003c/a>” in 2010, with acclaimed writer \u003ca title=\"Andrew Todhunter\" href=\"http://www.andrewtodhunter.com/about/index.html\">Andrew Todhunter\u003c/a> as co-director. The course is run like a creative writing workshop—a new experience for many of the students, who are mostly pre-medical. “A number of students come into the program saying ‘I’m not creative,'” says McConnell. But over the academic year they discover and develop their talents with the guidance of local artists. The HHMI grant money will fund honoraria for these creative mentors, as well as salaries for Todhunter and writing teacher Russ Carpenter.\u003c/p>\n\u003cp>“We see a lot of students taking important pieces of themselves and their science, and really trying to connect them,” McConnell says. One created a \u003ca title=\"Alwali - The Protecting Friend\" href=\"http://web.stanford.edu/~suemcc/TSR/styled-41/index.html\">graphic novel\u003c/a> about \u003ca title=\"WHO - Lymphatic filariasis\" href=\"http://www.who.int/mediacentre/factsheets/fs102/en/\">lymphatic filariasis\u003c/a>, a painful and disfiguring parasitic infection, hoping to help people she met during a summer internship in Bangladesh. A \u003ca title=\"Mallory Smith - Biome\" href=\"http://web.stanford.edu/~suemcc/TSR/styled-50/index.html\">student with cystic fibrosis\u003c/a> wrote and performed an \u003ca title=\"Biome\" href=\"https://soundcloud.com/mallorybeasmith/biome\">audio podcast\u003c/a> in which she draws parallels between the gradual destruction of her lungs and the environmental degradation of the planet.\u003c/p>\n\u003cp>[contextly_sidebar id=”7d58494988285dad810964dd5e43e48a”]\u003c/p>\n\u003cp>Doing art instead of research for their senior thesis certainly helps the graduates stand out. “It’s all the med school interviewers want to talk about,” McConnell says. But do any projects have the broader impact she hopes for?\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Some show promise. A \u003ca title=\"Neglected ~ A Story of Schistosomiasis Infection in Ghana -- Sand Animation\" href=\"https://www.youtube.com/watch?v=lo1cRLdqKq4\">2012 sand animation\u003c/a> about schistosomiasis was featured in \u003ci>Science\u003c/i> magazine. A \u003ca title=\"Brittany Margot - A Mother’s Choice\" href=\"http://web.stanford.edu/~suemcc/TSR/styled-10/index.html\">2013 quilt\u003c/a> portraying the science of breastfeeding now hangs in the maternity ward of Lucille Packard Children’s Hospital. And in both cases, the artists gained commissions for further work.\u003c/p>\n\u003cfigure id=\"attachment_19206\" class=\"wp-caption alignright\" style=\"max-width: 242px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Sue_McConnell_Elephants_1-242x162.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"wp-image-19206 size-medium\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Sue_McConnell_Elephants_1-242x162.jpg\" alt=\"A family of elephants in Namibia rescues its baby.\" width=\"242\" height=\"162\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A family of elephants in Namibia rescues its baby. Such images may inspire more conservation effort than simple information about the vulnerable status of African elephants. (Susan McConnell)\u003c/figcaption>\u003c/figure>\n\u003cp>As for the 2014 graduates, the author of the graphic novel plans to translate it into Bengali and distribute it in Bangladesh, to combat the extreme stigma associated with the disease. The cystic fibrosis piece, McConnell is certain, “will go national.” The full body of student work is open to public viewing all summer in the first floor of Wallenberg Hall on Stanford campus.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Art might seem like a counter-intuitive tool for communicating science, since it resonates with us emotionally rather than intellectually. But that resonance gives art the power to inspire, horrify, chasten, and motivate–a power that Sue McConnell is teaching the next generation of scientists and doctors to wield.\u003c/p>\n\n","blocks":[],"excerpt":"Stanford scientist Sue McConnell will receive $1 million over the next five years to sustain a program that teaches biology seniors to communicate science to the public through art.","status":"publish","parent":0,"modified":1704933308,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":11,"wordCount":631},"headData":{"title":"Communicating Science Through an Artistic Lens at Stanford | KQED","description":"Stanford scientist Sue McConnell will receive $1 million over the next five years to sustain a program that teaches biology seniors to communicate science to the public through art.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"sticky":false,"path":"/science/19200/communicating-science-through-an-artistic-lens-at-stanford","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_19209\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/lioncubs.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-19209\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/lioncubs.jpg\" alt=\"behavior of lion cubs in the wild\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The behavior of lion cubs in the wild is far removed from the study of brain development in the lab. Sue McConnell pays careful attention to both, one as a photographer and the other as a scientist. (Susan McConnell)\u003c/figcaption>\u003c/figure>\n\u003cp>Stanford scientist Sue McConnell will be one of 15 U.S. professors to receive $1 million over the next five years from the \u003ca title=\"HHMI 2014 Professors\" href=\"http://www.hhmi.org/news/hhmi-puts-top-scientists-classroom\">Howard Hughes Medical Institute\u003c/a>. The grant supports creative approaches to science education; McConnell will use it to sustain a program that teaches biology seniors to communicate science to the public through art.\u003c/p>\n\u003cfigure id=\"attachment_19204\" class=\"wp-caption alignright\" style=\"max-width: 267px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/page4-1089-full.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"wp-image-19204 size-full\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/page4-1089-full.jpg\" alt=\"Alwali - The Protecting Friend\" width=\"267\" height=\"383\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">“Alwali – The Protecting Friend,” a graphic novel by Rosy Karna about the science and stigma of lymphatic filariasis. (Susan McConnell)\u003c/figcaption>\u003c/figure>\n\u003cp>As a \u003ca title=\"McConnell Lab\" href=\"http://stanford.edu/group/skmlab/index.html\">developmental neurobiologist\u003c/a>, McConnell studies how brain cells are created and wired together, but she gets out of the lab in a dramatic way as a \u003ca title=\"McConnell Photography\" href=\"http://www.susankmcconnell.com/7-2/\">conservation photographer\u003c/a>. Her images of Namibian elephants have been on the cover of \u003ci>Smithsonian\u003c/i> magazine. “I understand how potent the arts can be in communicating science,” she says—a potency she sees as necessary for policy change. “It’s pretty clear that information isn’t having the impact on public decisions that we’d hoped.”\u003c/p>\n\u003cp>This view motivated McConnell to create “\u003ca title=\"The Senior Reflection\" href=\"http://web.stanford.edu/~suemcc/TSR/index.html\">The Senior Reflection\u003c/a>” in 2010, with acclaimed writer \u003ca title=\"Andrew Todhunter\" href=\"http://www.andrewtodhunter.com/about/index.html\">Andrew Todhunter\u003c/a> as co-director. The course is run like a creative writing workshop—a new experience for many of the students, who are mostly pre-medical. “A number of students come into the program saying ‘I’m not creative,'” says McConnell. But over the academic year they discover and develop their talents with the guidance of local artists. The HHMI grant money will fund honoraria for these creative mentors, as well as salaries for Todhunter and writing teacher Russ Carpenter.\u003c/p>\n\u003cp>“We see a lot of students taking important pieces of themselves and their science, and really trying to connect them,” McConnell says. One created a \u003ca title=\"Alwali - The Protecting Friend\" href=\"http://web.stanford.edu/~suemcc/TSR/styled-41/index.html\">graphic novel\u003c/a> about \u003ca title=\"WHO - Lymphatic filariasis\" href=\"http://www.who.int/mediacentre/factsheets/fs102/en/\">lymphatic filariasis\u003c/a>, a painful and disfiguring parasitic infection, hoping to help people she met during a summer internship in Bangladesh. A \u003ca title=\"Mallory Smith - Biome\" href=\"http://web.stanford.edu/~suemcc/TSR/styled-50/index.html\">student with cystic fibrosis\u003c/a> wrote and performed an \u003ca title=\"Biome\" href=\"https://soundcloud.com/mallorybeasmith/biome\">audio podcast\u003c/a> in which she draws parallels between the gradual destruction of her lungs and the environmental degradation of the planet.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>Doing art instead of research for their senior thesis certainly helps the graduates stand out. “It’s all the med school interviewers want to talk about,” McConnell says. But do any projects have the broader impact she hopes for?\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Some show promise. A \u003ca title=\"Neglected ~ A Story of Schistosomiasis Infection in Ghana -- Sand Animation\" href=\"https://www.youtube.com/watch?v=lo1cRLdqKq4\">2012 sand animation\u003c/a> about schistosomiasis was featured in \u003ci>Science\u003c/i> magazine. A \u003ca title=\"Brittany Margot - A Mother’s Choice\" href=\"http://web.stanford.edu/~suemcc/TSR/styled-10/index.html\">2013 quilt\u003c/a> portraying the science of breastfeeding now hangs in the maternity ward of Lucille Packard Children’s Hospital. And in both cases, the artists gained commissions for further work.\u003c/p>\n\u003cfigure id=\"attachment_19206\" class=\"wp-caption alignright\" style=\"max-width: 242px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Sue_McConnell_Elephants_1-242x162.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"wp-image-19206 size-medium\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Sue_McConnell_Elephants_1-242x162.jpg\" alt=\"A family of elephants in Namibia rescues its baby.\" width=\"242\" height=\"162\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A family of elephants in Namibia rescues its baby. Such images may inspire more conservation effort than simple information about the vulnerable status of African elephants. (Susan McConnell)\u003c/figcaption>\u003c/figure>\n\u003cp>As for the 2014 graduates, the author of the graphic novel plans to translate it into Bengali and distribute it in Bangladesh, to combat the extreme stigma associated with the disease. The cystic fibrosis piece, McConnell is certain, “will go national.” The full body of student work is open to public viewing all summer in the first floor of Wallenberg Hall on Stanford campus.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Art might seem like a counter-intuitive tool for communicating science, since it resonates with us emotionally rather than intellectually. But that resonance gives art the power to inspire, horrify, chasten, and motivate–a power that Sue McConnell is teaching the next generation of scientists and doctors to wield.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/science/19200/communicating-science-through-an-artistic-lens-at-stanford","authors":["6324"],"categories":["science_30"],"tags":["science_635","science_205","science_664","science_807","science_633","science_346"],"featImg":"science_19209","label":"science"},"science_10310":{"type":"posts","id":"science_10310","meta":{"index":"posts_1591205157","site":"science","id":"10310","score":null,"sort":[1382748779000]},"guestAuthors":[],"slug":"how-to-fly-a-model-helicopter-with-your-brain-and-other-adventures-in-eeg-gaming","title":"How to Fly a Model Helicopter With Your Brain and Other Adventures in EEG Gaming","publishDate":1382748779,"format":"aside","headTitle":"How to Fly a Model Helicopter With Your Brain and Other Adventures in EEG Gaming | KQED","labelTerm":{"site":"science"},"content":"\u003cdiv class=\"audio-wrap\">\n\u003ch2>Listen:\u003c/h2>\n\u003cp>http://www.kqed.org/.stream/anon/radio/science/2013/10/20131028science.mp3\u003c/p>\n\u003c/div>\n\u003cp>As audiences for the 2013 \u003ca href=\"http://www.youtube.com/embed/6dz2gdXP6Zs\">“Carrie”\u003c/a> re-make are finding out in theaters across the country, the power to move things with your mind can be hazardous to one’s well-being and pretty much everyone else’s, too.\u003c/p>\n\u003cp>My own experience with telekinesis, by contrast, was pretty tame.\u003c/p>\n\u003cp>\u003c!-- iframe plugin v.4.3 wordpress.org/plugins/iframe/ -->\u003cbr>\n\u003ciframe loading=\"lazy\" src=\"//instagram.com/p/fx0qiDI_Ka/embed/\" frameborder=\"0\" scrolling=\"no\" width=\"612\" height=\"710\" class=\"iframe-class\">\u003c/iframe>\u003c/p>\n\u003cp>\u003cem>In order to get the helicopter to fly, reporter Amy Standen, wearing a headset that captures her brain waves, has to concentrate on a single thought. She doesn’t have to think about the helicopter flying; it can be any thought, but she can’t be distracted and think, “Wow,” once the helicopter starts to fly.\u003c/em>\u003c/p>\n\u003cp>Technically, I’d have a hard time doing this without the use of an EEG headset, in this case the MindWave Mobile, which is made by a San Jose company called NeuroSky.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The MindWave Mobile—much like two other mobile brain-wave-sensing devices called the Emotiv and Interaxon—is a pared-down version of something you’ve seen in science fiction movies anytime someone’s head is covered in electrodes. It’s an EEG, or electroencephalogram.\u003c/p>\n\u003cp>The EEG is a device that measures electrical activity inside the brain. It’s good at revealing patterns, like what happens during an epileptic seizure, or during sleep. (Sleep scientists using an EEG discovered the REM, or rapid eye movement state.) It can also detect patterns associated with certain emotional states.\u003c/p>\n\u003cp>In recent years, these headsets have gotten easier to use and much less expensive; the MindWave Mobile costs $99. And this has encouraged developers to come up with ways to harness them for fun, by connecting mobile EEG headsets to other consumer devices like video games, smartphones and—as you see in the video above—miniature helicopters.\u003c/p>\n\u003cp>Johnny Liu, who directs the developer program at NeuroSky, came into the KQED studios recently to show me how to use a headset in combination with the \u003ca href=\"http://www.kickstarter.com/projects/puzzlebox/puzzlebox-orbit-brain-controlled-helicopter\">Puzzlebox Orbit Brain-Controlled Helicopter\u003c/a>. It’s a spherical cage about eight inches in diameter containing three small propellers. Liu positioned the headset’s single sensor over his forehead and powered up an iPad. Then, he just sat there.\u003c/p>\n\u003cfigure id=\"attachment_10324\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/Science_Drone_0017_web-e1382747907800.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/Science_Drone_0017_web-e1382747907800.jpg\" alt=\"The helicopter waits for the brain waves to kick in. (Sara Bloomberg/KQED)\" width=\"640\" height=\"360\" class=\"size-full wp-image-10324\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The helicopter waits for the brain waves to kick in. (Sara Bloomberg/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>“I’m driving up my attention level,” he explained.\u003c/p>\n\u003cp>Soon we had proof: A red bar on the iPad screen began to rise. When it passed the three-quarters mark, the helicopter’s propellers began to whir as the Orbit lifted from the table.\u003c/p>\n\u003cp>Telekinesis is a lot harder than it looks.\u003c/p>\n\u003cp>When it was my turn, Liu told me to pick something, anything, to focus on. I thought about the fog I’d seen on a walk that morning. Nothing. I fixedly pictured my breakfast. Zilch.\u003c/p>\n\u003cp>“How about you just try thinking about the helicopter?” Liu suggested.\u003c/p>\n\u003cp>It worked! For about three seconds. (The video above makes it look as if the helicopter flew after I focused on fog; that’s a flattering by-product of Instagram’s 15-second video limit.)\u003c/p>\n\u003cp>You can’t get frustrated with the helicopter, it turns out, because that’s different from concentration. You have to calmly focus on it, really hard.\u003c/p>\n\u003caside class=\"pullquote alignleft\">You’re doing the same thing as a meditator, a Buddhist monk might do. It’s just we in the West maybe need a device to do it.\u003c/aside>\n\u003cp>“Imagine,” Liu coached, “that you actually have telekinetic powers.”\u003c/p>\n\u003cp>Success: six seconds.\u003c/p>\n\u003cp>Fortunately for the aerodynamically challenged, there are other brain training devices in development. One is the \u003ca href=\"http://ericawarp.com/?projects=neurodisco\">NeuroDisco\u003c/a>, a prototype computer program that can be used with an EEG headset. It’s designed by the composer-husband and neuroscientist-wife team of Richard and Erica Warp, along with designer Chung-Hay Luk.\u003c/p>\n\u003cp>The NeuroDisco reads brainwaves from an EEG headset called the Emotiv, whose 16 sensors must be carefully positioned around the temples and the back of your head.\u003c/p>\n\u003cp>(Fruitlessly, in my case. Apparently I have too much hair—or not enough brain. The Emotiv failed to pick up a signal.)\u003c/p>\n\u003cp>Instead of flying a helicopter, the Emotive feeds brain signals wirelessly into a laptop, where the NeuroDisco, a computer program designed by Richard in composing software called Max/MSP, translates the brain’s electrical patterns into music.\u003c/p>\n\u003cp>The underlying beat corresponds to the type of emotional state. The Emotiv can’t read much of the range of human emotion, but it can, says Erica, “differentiate an excited state from a meditative state from a frustrated state, for example.”\u003c/p>\n\u003cfigure id=\"attachment_10326\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/Amyeeg2.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/Amyeeg2.jpg\" alt=\"Erica Warp explains to me how the NeuroDisco works. (Josh Cassidy/KQED)\" width=\"640\" height=\"427\" class=\"size-full wp-image-10326\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Erica Warp explains to me how the NeuroDisco works. (Sara Bloomberg/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>In a “frustrated” state, the beat is pounding and loud, “like a Nine Inch Nails song,” Richard says. As you become calmer and more meditative, the beat becomes softer and recedes.\u003c/p>\n\u003cp>[soundcloud url=”https://api.soundcloud.com/tracks/116956297″ width=”100%” height=”166″ iframe=”true” /]\u003c/p>\n\u003cp>The notes, meanwhile, correspond to the intensity, or “push” of the emotional state. The stronger your meditative state becomes, for instance, the closer the notes come together, the more “shimmery” the music sounds. A more distracted, less focused state produces tones that are farther away from each other and more discordant.\u003c/p>\n\u003cp>Richard, a former club-goer from London, says he wanted NeuroDisco’s music to be “subtle” and pleasant enough that a user might keep working with it, or as Richard puts it, “communing” with it. The idea is that over time, users will learn how to compose music by subtly changing their brain states, maybe increasing the intensity of their meditative states, for example.\u003c/p>\n\u003cp>Key to this learning process is the experience of biofeedback, where seeing a helicopter lift or hearing music shift tells the user in real time what his or her brain is doing and how it’s changing.\u003c/p>\n\u003cp>[soundcloud url=”https://api.soundcloud.com/tracks/116956835″ width=”100%” height=”166″ iframe=”true” /]\u003c/p>\n\u003cp>“That’s how you would train to be a brain musician,” says Richard. Instead of listening to the sounds the piano produces when you hit the keys, “you’re training to control your mental processes.”\u003c/p>\n\u003cp>Richard says he’s always been an anxious person. The desire to feel more grounded is part of what led him to work on this project.\u003c/p>\n\u003cp>“I was interested in creating an environment where people can really commune with their internal state,” he says.\u003c/p>\n\u003cp>But is more technology really what we need to help us relax? Haven’t people been communing with their internal states without technology for thousands of years?\u003c/p>\n\u003cp>At this, Warp laughs.\u003c/p>\n\u003cp>“You’re doing the same thing as a meditator, a Buddhist monk might do. It’s just we in the West maybe need a device to do it.”\u003c/p>\n\u003cp>I asked that question of Adam Gazzaley, a neuroscientist who studies distraction and technology at University of California-San Francisco: Is technology what we need to help us relax? What about taking a walk, or actually learning to meditate?\u003c/p>\n\u003cp>Gazzaley points out that for some people, that’s a lot to ask, particularly meditation.\u003c/p>\n\u003cp>“A lot of people find it really hard to get started, because they’re not very good at it in the beginning,” he says. EEG games can help engage those people by offering tools they’re comfortable with.\u003c/p>\n\u003cp>Perhaps for some, he adds, EEG feedback could one day be diagnostic—even therapeutic.\u003c/p>\n\u003cp>“Imagine your child is diagnosed with ADHD,” says Gazzaley, “and you take them to the doctor. Instead of being given a box of pills, they put an EEG cap on and they play a video game that looks at how they pay attention to relevant information, how they ignore information, how they sustain attention, how they deal with multiple tasks.”\u003c/p>\n\u003cp>Then, that data gets turned into a game—one the child will actually want to play—that can train him or her to focus more.\u003c/p>\n\u003cp>“Over time, they might see ‘wow, we’ve corrected those things and we didn’t need medication,’ or ‘we needed a lot less medication.’”\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>As for the rest of us, Gazzaley says, think of EEG games as baby steps toward learning new ways of calming down. Technology helped get us into this mess, maybe technology can help get us out.\u003c/p>\n\n","blocks":[],"excerpt":"In recent years EEGs, devices that measure brain waves, have gotten easier to use and much less expensive. They used to be mainly for scientific and medical research, but now developers are coming up with ways to harness them for fun.","status":"publish","parent":0,"modified":1704934811,"stats":{"hasAudio":true,"hasVideo":true,"hasChartOrMap":true,"iframeSrcs":["//instagram.com/p/fx0qiDI_Ka/embed/"],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":45,"wordCount":1481},"headData":{"title":"How to Fly a Model Helicopter With Your Brain and Other Adventures in EEG Gaming | KQED","description":"In recent years EEGs, devices that measure brain waves, have gotten easier to use and much less expensive. They used to be mainly for scientific and medical research, but now developers are coming up with ways to harness them for fun.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"audioUrl":"http://www.kqed.org/.stream/anon/radio/science/2013/10/20131028science.mp3","sticky":false,"path":"/science/10310/how-to-fly-a-model-helicopter-with-your-brain-and-other-adventures-in-eeg-gaming","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cdiv class=\"audio-wrap\">\n\u003ch2>Listen:\u003c/h2>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"audioLink","attributes":{"named":{"src":"http://www.kqed.org/.stream/anon/radio/science/2013/10/20131028science.mp3"},"numeric":[]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/div>\n\u003cp>As audiences for the 2013 \u003ca href=\"http://www.youtube.com/embed/6dz2gdXP6Zs\">“Carrie”\u003c/a> re-make are finding out in theaters across the country, the power to move things with your mind can be hazardous to one’s well-being and pretty much everyone else’s, too.\u003c/p>\n\u003cp>My own experience with telekinesis, by contrast, was pretty tame.\u003c/p>\n\u003cp>\u003c!-- iframe plugin v.4.3 wordpress.org/plugins/iframe/ -->\u003cbr>\n\u003ciframe loading=\"lazy\" src=\"//instagram.com/p/fx0qiDI_Ka/embed/\" frameborder=\"0\" scrolling=\"no\" width=\"612\" height=\"710\" class=\"iframe-class\">\u003c/iframe>\u003c/p>\n\u003cp>\u003cem>In order to get the helicopter to fly, reporter Amy Standen, wearing a headset that captures her brain waves, has to concentrate on a single thought. She doesn’t have to think about the helicopter flying; it can be any thought, but she can’t be distracted and think, “Wow,” once the helicopter starts to fly.\u003c/em>\u003c/p>\n\u003cp>Technically, I’d have a hard time doing this without the use of an EEG headset, in this case the MindWave Mobile, which is made by a San Jose company called NeuroSky.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The MindWave Mobile—much like two other mobile brain-wave-sensing devices called the Emotiv and Interaxon—is a pared-down version of something you’ve seen in science fiction movies anytime someone’s head is covered in electrodes. It’s an EEG, or electroencephalogram.\u003c/p>\n\u003cp>The EEG is a device that measures electrical activity inside the brain. It’s good at revealing patterns, like what happens during an epileptic seizure, or during sleep. (Sleep scientists using an EEG discovered the REM, or rapid eye movement state.) It can also detect patterns associated with certain emotional states.\u003c/p>\n\u003cp>In recent years, these headsets have gotten easier to use and much less expensive; the MindWave Mobile costs $99. And this has encouraged developers to come up with ways to harness them for fun, by connecting mobile EEG headsets to other consumer devices like video games, smartphones and—as you see in the video above—miniature helicopters.\u003c/p>\n\u003cp>Johnny Liu, who directs the developer program at NeuroSky, came into the KQED studios recently to show me how to use a headset in combination with the \u003ca href=\"http://www.kickstarter.com/projects/puzzlebox/puzzlebox-orbit-brain-controlled-helicopter\">Puzzlebox Orbit Brain-Controlled Helicopter\u003c/a>. It’s a spherical cage about eight inches in diameter containing three small propellers. Liu positioned the headset’s single sensor over his forehead and powered up an iPad. Then, he just sat there.\u003c/p>\n\u003cfigure id=\"attachment_10324\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/Science_Drone_0017_web-e1382747907800.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/Science_Drone_0017_web-e1382747907800.jpg\" alt=\"The helicopter waits for the brain waves to kick in. (Sara Bloomberg/KQED)\" width=\"640\" height=\"360\" class=\"size-full wp-image-10324\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The helicopter waits for the brain waves to kick in. (Sara Bloomberg/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>“I’m driving up my attention level,” he explained.\u003c/p>\n\u003cp>Soon we had proof: A red bar on the iPad screen began to rise. When it passed the three-quarters mark, the helicopter’s propellers began to whir as the Orbit lifted from the table.\u003c/p>\n\u003cp>Telekinesis is a lot harder than it looks.\u003c/p>\n\u003cp>When it was my turn, Liu told me to pick something, anything, to focus on. I thought about the fog I’d seen on a walk that morning. Nothing. I fixedly pictured my breakfast. Zilch.\u003c/p>\n\u003cp>“How about you just try thinking about the helicopter?” Liu suggested.\u003c/p>\n\u003cp>It worked! For about three seconds. (The video above makes it look as if the helicopter flew after I focused on fog; that’s a flattering by-product of Instagram’s 15-second video limit.)\u003c/p>\n\u003cp>You can’t get frustrated with the helicopter, it turns out, because that’s different from concentration. You have to calmly focus on it, really hard.\u003c/p>\n\u003caside class=\"pullquote alignleft\">You’re doing the same thing as a meditator, a Buddhist monk might do. It’s just we in the West maybe need a device to do it.\u003c/aside>\n\u003cp>“Imagine,” Liu coached, “that you actually have telekinetic powers.”\u003c/p>\n\u003cp>Success: six seconds.\u003c/p>\n\u003cp>Fortunately for the aerodynamically challenged, there are other brain training devices in development. One is the \u003ca href=\"http://ericawarp.com/?projects=neurodisco\">NeuroDisco\u003c/a>, a prototype computer program that can be used with an EEG headset. It’s designed by the composer-husband and neuroscientist-wife team of Richard and Erica Warp, along with designer Chung-Hay Luk.\u003c/p>\n\u003cp>The NeuroDisco reads brainwaves from an EEG headset called the Emotiv, whose 16 sensors must be carefully positioned around the temples and the back of your head.\u003c/p>\n\u003cp>(Fruitlessly, in my case. Apparently I have too much hair—or not enough brain. The Emotiv failed to pick up a signal.)\u003c/p>\n\u003cp>Instead of flying a helicopter, the Emotive feeds brain signals wirelessly into a laptop, where the NeuroDisco, a computer program designed by Richard in composing software called Max/MSP, translates the brain’s electrical patterns into music.\u003c/p>\n\u003cp>The underlying beat corresponds to the type of emotional state. The Emotiv can’t read much of the range of human emotion, but it can, says Erica, “differentiate an excited state from a meditative state from a frustrated state, for example.”\u003c/p>\n\u003cfigure id=\"attachment_10326\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/Amyeeg2.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/Amyeeg2.jpg\" alt=\"Erica Warp explains to me how the NeuroDisco works. (Josh Cassidy/KQED)\" width=\"640\" height=\"427\" class=\"size-full wp-image-10326\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Erica Warp explains to me how the NeuroDisco works. (Sara Bloomberg/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>In a “frustrated” state, the beat is pounding and loud, “like a Nine Inch Nails song,” Richard says. As you become calmer and more meditative, the beat becomes softer and recedes.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cdiv class='utils-parseShortcode-shortcodes-__shortcodes__shortcodeWrapper'>\n \u003ciframe width='”100%”' height='”166″'\n scrolling='no' frameborder='no'\n src='https://w.soundcloud.com/player/?url=”https://api.soundcloud.com/tracks/116956297″&visual=true&undefined'\n title='”https://api.soundcloud.com/tracks/116956297″'>\n \u003c/iframe>\n \u003c/div>\u003c/p>\u003cp>\u003c/p>\n\u003cp>The notes, meanwhile, correspond to the intensity, or “push” of the emotional state. The stronger your meditative state becomes, for instance, the closer the notes come together, the more “shimmery” the music sounds. A more distracted, less focused state produces tones that are farther away from each other and more discordant.\u003c/p>\n\u003cp>Richard, a former club-goer from London, says he wanted NeuroDisco’s music to be “subtle” and pleasant enough that a user might keep working with it, or as Richard puts it, “communing” with it. The idea is that over time, users will learn how to compose music by subtly changing their brain states, maybe increasing the intensity of their meditative states, for example.\u003c/p>\n\u003cp>Key to this learning process is the experience of biofeedback, where seeing a helicopter lift or hearing music shift tells the user in real time what his or her brain is doing and how it’s changing.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cdiv class='utils-parseShortcode-shortcodes-__shortcodes__shortcodeWrapper'>\n \u003ciframe width='”100%”' height='”166″'\n scrolling='no' frameborder='no'\n src='https://w.soundcloud.com/player/?url=”https://api.soundcloud.com/tracks/116956835″&visual=true&undefined'\n title='”https://api.soundcloud.com/tracks/116956835″'>\n \u003c/iframe>\n \u003c/div>\u003c/p>\u003cp>\u003c/p>\n\u003cp>“That’s how you would train to be a brain musician,” says Richard. Instead of listening to the sounds the piano produces when you hit the keys, “you’re training to control your mental processes.”\u003c/p>\n\u003cp>Richard says he’s always been an anxious person. The desire to feel more grounded is part of what led him to work on this project.\u003c/p>\n\u003cp>“I was interested in creating an environment where people can really commune with their internal state,” he says.\u003c/p>\n\u003cp>But is more technology really what we need to help us relax? Haven’t people been communing with their internal states without technology for thousands of years?\u003c/p>\n\u003cp>At this, Warp laughs.\u003c/p>\n\u003cp>“You’re doing the same thing as a meditator, a Buddhist monk might do. It’s just we in the West maybe need a device to do it.”\u003c/p>\n\u003cp>I asked that question of Adam Gazzaley, a neuroscientist who studies distraction and technology at University of California-San Francisco: Is technology what we need to help us relax? What about taking a walk, or actually learning to meditate?\u003c/p>\n\u003cp>Gazzaley points out that for some people, that’s a lot to ask, particularly meditation.\u003c/p>\n\u003cp>“A lot of people find it really hard to get started, because they’re not very good at it in the beginning,” he says. EEG games can help engage those people by offering tools they’re comfortable with.\u003c/p>\n\u003cp>Perhaps for some, he adds, EEG feedback could one day be diagnostic—even therapeutic.\u003c/p>\n\u003cp>“Imagine your child is diagnosed with ADHD,” says Gazzaley, “and you take them to the doctor. Instead of being given a box of pills, they put an EEG cap on and they play a video game that looks at how they pay attention to relevant information, how they ignore information, how they sustain attention, how they deal with multiple tasks.”\u003c/p>\n\u003cp>Then, that data gets turned into a game—one the child will actually want to play—that can train him or her to focus more.\u003c/p>\n\u003cp>“Over time, they might see ‘wow, we’ve corrected those things and we didn’t need medication,’ or ‘we needed a lot less medication.’”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>As for the rest of us, Gazzaley says, think of EEG games as baby steps toward learning new ways of calming down. Technology helped get us into this mess, maybe technology can help get us out.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/science/10310/how-to-fly-a-model-helicopter-with-your-brain-and-other-adventures-in-eeg-gaming","authors":["210"],"categories":["science_89","science_39","science_40"],"tags":["science_64","science_807"],"featImg":"science_10320","label":"science"},"science_9862":{"type":"posts","id":"science_9862","meta":{"index":"posts_1591205157","site":"science","id":"9862","score":null,"sort":[1381762837000]},"guestAuthors":[],"slug":"infections-during-pregnancy-may-increase-autism-risk","title":"Infections During Pregnancy May Increase Autism Risk","publishDate":1381762837,"format":"aside","headTitle":"Infections During Pregnancy May Increase Autism Risk | KQED","labelTerm":{"site":"science"},"content":"\u003cfigure id=\"attachment_9865\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/PregnantWomanSitting_flickr_StuartHandy_3235768334_6beed51726_z_640x360.jpg\" rel=\"attachment wp-att-9865\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9865\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/PregnantWomanSitting_flickr_StuartHandy_3235768334_6beed51726_z_640x360.jpg\" alt=\"Photograph courtesy of Stuart Handy via a Creative Commons license.\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Photograph courtesy of \u003ca href=\"http://www.flickr.com/photos/8274310@N07/3235768334/\" target=\"_blank\" rel=\"noopener\">Stuart Handy\u003c/a> via a Creative Commons license.\u003c/figcaption>\u003c/figure>\n\u003cp>Every day our brains help us make sense of the world around us, interpreting the experiences we see, hear, taste, touch and smell. But if someone’s brain has trouble processing this incoming information, it can be hard to communicate, understand or learn.\u003c/p>\n\u003cp>Autism spectrum disorders (ASD) are characterized by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors. These disorders include \u003ca href=\"http://science.kqed.org/quest/video/autism-searching-for-causes/\" target=\"_blank\" rel=\"noopener\">autism\u003c/a>, \u003ca href=\"http://en.wikipedia.org/wiki/Asperger_syndrome\" target=\"_blank\" rel=\"noopener\">Asperger syndrome\u003c/a> and p\u003ca href=\"http://en.wikipedia.org/wiki/PDD-NOS\" target=\"_blank\" rel=\"noopener\">ervasive developmental disorder-not otherwise specified\u003c/a> (PDD-NOS).\u003c/p>\n\u003cp>About \u003ca title=\"CDC Fact Sheet for Autism Spectrum Disorders\" href=\"http://www.cdc.gov/ncbddd/autism/data.html\">one in 88 children\u003c/a> have been identified with an autism spectrum disorder, and over 2 million people are affected in the United States, according to the Centers for Disease Control and Prevention. Government statistics also suggest that the proportion of people with autism spectrum disorders have increased \u003ca title=\"Autism Speaks Frequently Asked Questions\" href=\"http://www.autismspeaks.org/what-autism/faq\">10 to 17 percent annually\u003c/a> in recent years. This is in part due to wider awareness and better screening, but the continued increase is not fully understood.\u003c/p>\n\u003cp>The cause of ASD is also not fully known, but current research indicates that it is likely due to a complex combination of genetic predisposition and environmental risk factors that influence early brain development. Significant environmental risk factors include the advance age of either parent at the time of conception, maternal illness during pregnancy, extreme prematurity and very low birth weight.\u003c/p>\n\u003cp>Over 40 years ago, \u003ca title=\"journal review article\" href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435446/pdf/nihms396261.pdf\">epidemiological studies\u003c/a> determined that the risk of having a child with ASD is increased when the mother has an infection early in the pregnancy. Since a wide range of bacterial and viral infections can increase the risk, studies suggest that activation of the mother’s general immune system is responsible. However, scientists do not completely understand how the activated immune system can disrupt normal brain development to cause ASD.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Research at the UC Davis’ Center for Neuroscience provides new insight. Recently \u003ca title=\"UCD journal article in Journal of Neuroscience\" href=\"http://www.jneurosci.org/content/33/34/13791.abstract\">published in the \u003cem>Journal of Neuroscience\u003c/em>\u003c/a>, their studies identify a new biological mechanism that links maternal immune activation to neurodevelopmental disorders.\u003c/p>\n\u003cp>Kimberley McAllister, a senior author of the study, explained in a \u003ca title=\"press release\" href=\"http://www.ucdmc.ucdavis.edu/publish/news/newsroom/8208\">press release\u003c/a>, “This is the first evidence that neurons in the developing brain of newborn offspring are altered by maternal immune activation. Until now, very little has been known about how maternal immune activation leads to autism spectrum disorder and schizophrenia-like pathophysiology and behaviors in the offspring.”\u003c/p>\n\u003cp>The researchers studied pregnant mice with immune systems that were activated halfway through gestation compared to pregnant control mice without activated immune systems. They found that the mice exposed to a viral infection had offspring with dramatically elevated levels of immune molecules called major histocompatibility complex 1 (MHC1) on their brain surface.\u003c/p>\n\u003cp>In the affected newborn mice, these high levels of MCH1 disrupted the development of neural cells in the brain. Specifically, the increase in MCH1 interfered with the neurons’ ability to form the synapses that allow neurons to pass electrical or chemical signals to other cells; consequently, these offspring had less than half as many synapses than the control offspring. When MCH1 were returned to normal levels in the neurons of maternal immune-activated offspring, the synapses density returned to normal.\u003c/p>\n\u003cp>However, MCH1 doesn’t work alone. In a series of additional experiments, the researchers identified the new biological signaling pathway that regulates synapses development caused by maternal immune activation. This signaling pathway requires calcineurin, myocyte enhancer factor-2 and MCH1 to limit synapses density.\u003c/p>\n\u003cp>A better understanding of the underlying biological mechanisms will hopefully lead to the development of improved prenatal health screening, diagnostic tests and eventually therapies for neurodevelopmental disorders.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Of course, not every child of a bacterially or virally infected mother develops a neurodevelopmental disorder like autism. The effect of maternal immune activation depends on a complex interaction involving the strength of the infection and \u003ca title=\"Autism Speaks fact sheet\" href=\"http://www.autismspeaks.org/what-autism/faq\">genetic predisposition\u003c/a>.\u003c/p>\n\n","blocks":[],"excerpt":"Research at UC Davis identifies a new biological mechanism that links maternal infections during pregnancy to increased risk of having a child with a neurodevelopmental disorder like autism. ","status":"publish","parent":0,"modified":1704934892,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":14,"wordCount":637},"headData":{"title":"Infections During Pregnancy May Increase Autism Risk | KQED","description":"Research at UC Davis identifies a new biological mechanism that links maternal infections during pregnancy to increased risk of having a child with a neurodevelopmental disorder like autism. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"sticky":false,"path":"/science/9862/infections-during-pregnancy-may-increase-autism-risk","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_9865\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/PregnantWomanSitting_flickr_StuartHandy_3235768334_6beed51726_z_640x360.jpg\" rel=\"attachment wp-att-9865\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9865\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2013/10/PregnantWomanSitting_flickr_StuartHandy_3235768334_6beed51726_z_640x360.jpg\" alt=\"Photograph courtesy of Stuart Handy via a Creative Commons license.\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Photograph courtesy of \u003ca href=\"http://www.flickr.com/photos/8274310@N07/3235768334/\" target=\"_blank\" rel=\"noopener\">Stuart Handy\u003c/a> via a Creative Commons license.\u003c/figcaption>\u003c/figure>\n\u003cp>Every day our brains help us make sense of the world around us, interpreting the experiences we see, hear, taste, touch and smell. But if someone’s brain has trouble processing this incoming information, it can be hard to communicate, understand or learn.\u003c/p>\n\u003cp>Autism spectrum disorders (ASD) are characterized by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors. These disorders include \u003ca href=\"http://science.kqed.org/quest/video/autism-searching-for-causes/\" target=\"_blank\" rel=\"noopener\">autism\u003c/a>, \u003ca href=\"http://en.wikipedia.org/wiki/Asperger_syndrome\" target=\"_blank\" rel=\"noopener\">Asperger syndrome\u003c/a> and p\u003ca href=\"http://en.wikipedia.org/wiki/PDD-NOS\" target=\"_blank\" rel=\"noopener\">ervasive developmental disorder-not otherwise specified\u003c/a> (PDD-NOS).\u003c/p>\n\u003cp>About \u003ca title=\"CDC Fact Sheet for Autism Spectrum Disorders\" href=\"http://www.cdc.gov/ncbddd/autism/data.html\">one in 88 children\u003c/a> have been identified with an autism spectrum disorder, and over 2 million people are affected in the United States, according to the Centers for Disease Control and Prevention. Government statistics also suggest that the proportion of people with autism spectrum disorders have increased \u003ca title=\"Autism Speaks Frequently Asked Questions\" href=\"http://www.autismspeaks.org/what-autism/faq\">10 to 17 percent annually\u003c/a> in recent years. This is in part due to wider awareness and better screening, but the continued increase is not fully understood.\u003c/p>\n\u003cp>The cause of ASD is also not fully known, but current research indicates that it is likely due to a complex combination of genetic predisposition and environmental risk factors that influence early brain development. Significant environmental risk factors include the advance age of either parent at the time of conception, maternal illness during pregnancy, extreme prematurity and very low birth weight.\u003c/p>\n\u003cp>Over 40 years ago, \u003ca title=\"journal review article\" href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435446/pdf/nihms396261.pdf\">epidemiological studies\u003c/a> determined that the risk of having a child with ASD is increased when the mother has an infection early in the pregnancy. Since a wide range of bacterial and viral infections can increase the risk, studies suggest that activation of the mother’s general immune system is responsible. However, scientists do not completely understand how the activated immune system can disrupt normal brain development to cause ASD.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Research at the UC Davis’ Center for Neuroscience provides new insight. Recently \u003ca title=\"UCD journal article in Journal of Neuroscience\" href=\"http://www.jneurosci.org/content/33/34/13791.abstract\">published in the \u003cem>Journal of Neuroscience\u003c/em>\u003c/a>, their studies identify a new biological mechanism that links maternal immune activation to neurodevelopmental disorders.\u003c/p>\n\u003cp>Kimberley McAllister, a senior author of the study, explained in a \u003ca title=\"press release\" href=\"http://www.ucdmc.ucdavis.edu/publish/news/newsroom/8208\">press release\u003c/a>, “This is the first evidence that neurons in the developing brain of newborn offspring are altered by maternal immune activation. Until now, very little has been known about how maternal immune activation leads to autism spectrum disorder and schizophrenia-like pathophysiology and behaviors in the offspring.”\u003c/p>\n\u003cp>The researchers studied pregnant mice with immune systems that were activated halfway through gestation compared to pregnant control mice without activated immune systems. They found that the mice exposed to a viral infection had offspring with dramatically elevated levels of immune molecules called major histocompatibility complex 1 (MHC1) on their brain surface.\u003c/p>\n\u003cp>In the affected newborn mice, these high levels of MCH1 disrupted the development of neural cells in the brain. Specifically, the increase in MCH1 interfered with the neurons’ ability to form the synapses that allow neurons to pass electrical or chemical signals to other cells; consequently, these offspring had less than half as many synapses than the control offspring. When MCH1 were returned to normal levels in the neurons of maternal immune-activated offspring, the synapses density returned to normal.\u003c/p>\n\u003cp>However, MCH1 doesn’t work alone. In a series of additional experiments, the researchers identified the new biological signaling pathway that regulates synapses development caused by maternal immune activation. This signaling pathway requires calcineurin, myocyte enhancer factor-2 and MCH1 to limit synapses density.\u003c/p>\n\u003cp>A better understanding of the underlying biological mechanisms will hopefully lead to the development of improved prenatal health screening, diagnostic tests and eventually therapies for neurodevelopmental disorders.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Of course, not every child of a bacterially or virally infected mother develops a neurodevelopmental disorder like autism. The effect of maternal immune activation depends on a complex interaction involving the strength of the infection and \u003ca title=\"Autism Speaks fact sheet\" href=\"http://www.autismspeaks.org/what-autism/faq\">genetic predisposition\u003c/a>.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/science/9862/infections-during-pregnancy-may-increase-autism-risk","authors":["6360"],"categories":["science_30","science_39"],"tags":["science_807","science_616"],"featImg":"science_9865","label":"science"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. 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